The nasolabial folds are also known as the “parentheses” around the mouth. These grooves form from a combination of smiling and sagging of the cheek. The most common treatment for these is to inject filler directly into the fold to reduce the severity of the appearance. Another method we like at Advanced Dermatology is to use filler into the cheeks. This elevates the cheeks and reduces the nasolabial folds; it also rejuvenates the appearance of the face more than direct injection of the folds. The folds can also be reduced by tissue tightening devices and some laser procedures.