A New GLP-1 Side Effect Patients Are Talking About: “Ozempic Vulva” and How EMSELLA® Helps

Over the last two years, we’ve highlighted many of the changes patients may experience while using GLP-1 medications such as Ozempic®, Wegovy®, Mounjaro®, and Zepbound®. In previous newsletters, we discussed common concerns like facial volume loss, skin laxity, and dryness, and how our treatment offerings can help restore balance and confidence. As these medications become more widely used, new concerns continue to emerge, one of the latest gaining attention is something patients and influencers are calling “Ozempic Vulva.”

Although not a medical term, “Ozempic Vulva” describes changes in support, tone, and overall comfort in the vulvar and pelvic-floor region that may develop after significant or rapid weight loss. When tissue volume decreases quickly, the mons pubis, labia majora, and pelvic floor muscles can lose some of the natural support they previously provided. Many patients describe feeling less supported or noticing a sensation of looseness or pressure that wasn’t present before their weight loss. Some also experience mild urinary leakage during activities like coughing, sneezing, or exercising. These concerns can be unexpected and understandably affect not only physical comfort but also confidence and intimacy.

Fortunately, an effective, non-invasive treatment exists to address the core issue behind these symptoms. EMSELLA® uses high-intensity focused electromagnetic (HIFEM) energy to rapidly contract and rebuild the pelvic floor muscles, delivering the equivalent of more than eleven thousand Kegel contractions in a single session. By strengthening the internal muscular support system, EMSELLA® helps restore stability and improve overall comfort in the vulvar region. The treatment is performed fully clothed, requires no downtime, and is typically completed as a series of six sessions over the course of a few weeks. Many patients begin noticing improvements within the first few treatments as strength and support gradually return.

To complement in-office pelvic floor strengthening, patients may also benefit from targeted at-home vaginal rejuvenation. CO2Lift V (3 Pack, $330), available at skinfo®, is an advanced carboxytherapy gel treatment designed specifically for vaginal and vulvar tissue health. This at-home kit helps improve hydration, elasticity, and overall tissue quality by delivering a surge of carbon dioxide to gently stimulate increased oxygenation and circulation to the area. For individuals experiencing dryness, irritation, or changes in comfort following rapid weight loss, CO2Lift V can provide a soothing, restorative boost between EMSELLA® sessions or as a maintenance option.

Together, EMSELLA® and CO2Lift V offer a comprehensive approach to regaining strength, comfort, and confidence after GLP-1–related changes. If you’ve noticed shifts in the vulvar or pelvic area after weight loss, know that you’re not alone, and that effective, science-backed solutions are available. Our team is here to help guide you through your options and determine the best plan for your needs.