Wrinkles around the lips can be due to genetics, smoking , and sun damage. The best treatment for lip lines is different for each patient. Lip wrinkles can be treated with injectable fillers such as hyaluronic acids, and/or have botulinum toxin injected to reduce their severity. Sublative rejuvenation (Ematrix) is a good method for less severe lines. Fractionated CO2 (CO2RE) is an excellent treatment for difficult deep lip lines.